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KMID : 0351619680090010085
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Kyungpook Medical Journal
1968 Volume.9 No. 1 p.85 ~ p.91
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Study on the Effect of Cortisone to the Growth of the Chick Evbryo by Counting the Isolated Nuclei from Cells
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李錫潤/Lee, Seok Yoon
權誠鎭/尹周式/陳丁煥/Kwon, Sung Jin/Yoon, Joo Shic/Jin, Jung Hwan
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Abstract
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Each 0.5mg and 2.0mg of cortison acetate were injected to each subdivided group of 8th day and 12th day incubated chick embryo to study the effect of the cortisone on the growth of the chick embryo, expecially the parenchymatous organs such as brain, kidney and liver by counting the isolated nuclei from cells of these organs and the results were obtained as followings.
1) In general, the embryo group injected cortisone at 8th day of incubation were noted a growth suppression in comparison with the embryo group injection cortisone at 12th day of incuation.
2) In the brain, kidney and liver, the embryo group injected cortisone at 8the day in incubation revealed a low nuclear density per unit volume of organs in comparison with the embryo group injected cortisone at 12th day of incubation(P<0.01).
3) In the brain, kidney and liver, the embryo group injected cortisone at 8th day of incubation revealed a decreased total nuclear number in comparison with the embryo group injected cortisone at 12th day of incubation.
4) Though there was no marked change in number of total nuclei in liver and brain depending upon the change of amount of cortisone injected, in general, in the embryo group cortisone injected at 8the day of incubation, cortisone 2.0mg injected embryo group revealed more suppression in growth than the group injected 0.5mg of cortisone.
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